Why blastocysts dont implant

When it comes to the embryo, there are two ways to tell if it has the potential to implant and grow into a baby, including PGS and the embryo grade. As for the uterine environment, our New Jersey fertility specialist explains that mechanical problems within the uterine cavity can cause implantation failure.

Not only can an endometrial biopsy identify inflammatory problems and infections in the uterus, it can also determine the best time to transfer an embryo. Our New Jersey fertility doctor believes that taking a careful, detailed patient history can help diagnose problems with embryo genetics, embryo grade and uterine receptivity. Contact our New Jersey fertility specialist to schedule an appointment and learn more about the causes of implantation failure.

Monday am - pm Tuesday am - pm Wednesday am - pm Thursday am - pm Friday am - pm Saturday Closed Sunday Closed. Our New Jersey fertility specialist explains implantation failure.

Our New Jersey fertility specialist explains implantation failure Jane Miller MD utilizes her experience and the latest techniques in reproductive medicine to help patients achieve successful pregnancies, but sometimes implantation failure can occur. PGS will tell us if an embryo has the correct chromosomal makeup to develop into a healthy baby. The embryo grade the scoring assigned by the embryologist will tell us if there are enough cells to make a baby. In natural cycles, the window may be d wide, but in our treatments in can be only h long.

This window is controlled by the hormone progesterone. The timing, dose and route of administration of progesterone can impact this. This provides us with a tool to work with in this specific group , and we have done well with our patients with abnormal testing.

However, the ERA has not yet been proven to be useful for patients just starting their evaluation, undergoing simple treatments or just starting IVF. Hopefully, over the next couple of years, we will have information as to whether it is helpful in those situations. The lining normally needs to reach a certain thickness about 7 mm to give an embryo a good chance of implanting. Pregnancies can occur with thinner linings, but they are much less likely to occur and the resulting pregnancies can be more complicated.

In some women, thin linings occur due to the lining being damaged surgically, but in many women, we have no obvious reason for the thin lining. For these women, a variety of treatments have been tried estrogen, aspirin, sildenafil, pentoxifylline, Vitamin E and gCSF , but unfortunately they do not have significant impact for most patients.

Chronic endometritis is a disorder where there is inflammation in the lining of the uterus. Endometritis is very uncommon and thus we do not subject our patients to painful biopsies to detect it routinely. However, when we have not been successful, it is something to consider looking for.

Treatment with antibiotics is usually effective when endometritis is found. Evidence continues to mount that the lining of the uterus in endometriosis patients is different and may well be contributing to infertility beyond the clear anatomic issues seen at surgery with advance stages of endometriosis.

Since we are no longer performing laparoscopy on everyone, this is something that can be missed. The mechanism appears to be related to progesterone resistance at a molecular level. Fortunately, it appears that the significant doses of progesterone used in ART treatments overcome this. Technical Issues. Embryo transfer is a subtle technique that not everyone can do. The procedure needs to be atraumatic to avoid uterine contractions and minimize disrupting the endometrium.

Transfers need to be done quickly, so that the embryos are not subject to metabolic stress while awaiting transfer. The embryos need to be placed in the proper position in the uterus for optimal implantation and to avoid tubal and cervical pregnancies.

It takes very little to sabotage this. Well, it is the usual suspects here. Pregnancy rates also appear to be lower when the man is obese, even with normal sperm parameters. Of course, pregnancies can be substantially more risky as our weight increases.

Cigarette smoking is another modifiable factor that appears to have its primary manifestation through altering ovarian function and oocyte quality. However, in studies of oocyte donation recipients, the clinical pregnancy rate was reduced by a third, clearly indicating an effect on the lining of the uterus as well. Thyroid dysfunction, certain antibodies and elevated prolactin levels do not appear to affect chances of pregnancy through assisted reproductive technologies such as in vitro fertilization.

Vitamin D deficiency is common and is important to look at since the active form of vitamin D is secreted by the endometrium and impacts genes essential for implantation. Embryos with abnormal chromosome numbers embryonic aneuploidy are clearly the most common reason for IVF failure, and has led to the development of our current embryo testing approach.

However, there are a variety of other issues that impact egg development and embryo performance that can lead to the failure of implantation of a chromosomally normal embryo. Are you better off with an experienced reproductive endocrinologist with a long track record, or a new young doctor just off fellowship training who may be at the cutting edge of practice?

Does the lab have a good reputation and experienced staff? Do you feel comfortable that your doctor is listening to you and is addressing your concerns? Before you commit to a second IVF cycle, assess how you and your partner feel. Many fertility clinics require women to stop smoking at least three months before starting IVF treatment. Women who are overweight or underweight are less likely to have successful IVF treatment.

The bottom line is, maintain a healthy weight. If you are overweight,losing as little as 10 percent of your body weight can make a positive difference in your ability to get pregnant. The bundle is tailored for your specific treatment plan, and you only pay for the treatment you need, unlike traditional multi-cycle discount plans in which you pay for up to 6 attempts that you may never need in order to receive a discount.

For those patients who think they may need an additional IVF attempt to become pregnant, the. Are you ready to take the next step? Visit www. Top 6 Reasons for Failed Fertility Treatments.